Chevance, A., P. Ravaud, V. Cornelius, E. Mayo-Wilson and T. A. Furukawa (2022). “Designing clinically useful psychopharmacological trials: challenges and ways forward.” The Lancet Psychiatry. (https://authors.elsevier.com/c/1f0p37tf1d1D4U)

Methods to enhance clinical usefulness of drug RCTs to support therapeutic decisions include: embedding pragmatic RCTs within clinical practice to improve generalisability to target populations; collecting evidence about drugs in overlooked populations; developing methods to facilitate the recruitment of patients with mental disorders and to reduce the number of patients who drop out, using specific methods; using core outcome sets to standardise the assessment of benefits and harms; and recording systematically serious objective outcomes, such as suicide or hospitalisation, to be evaluated in meta-analyses.