Special lecture　特別講義

Recent advances in network meta-analysis
— Based on the invited lecture “The march of evidence synthesis: which limits are we pushing?” at the International Biostatistical Society in Lausanne, Switzerland (September 9-12, 2019)

Date & Place

June 26th, Wednesday, 2019
18:00-19:00
先端棟1階大セミナー室

Abstract

Network meta-analysis has been in the forefront of evidence synthesis for the last fifteen years. It has been used to support health technology assessment and medical decision-making at large. However, it can no longer keep pace with the ever-increasing complexity of questions that patients and decision-makers pose.

I will outline the limitations of network meta-analysis, summarize research in progress, and discuss needed methodological advances. With those limitations in mind, current research is directed at a) methods to answer treatment hierarchy questions, b) synthesis of data from varying sources such as trials, registries, single arm studies, c) making personalized predictions for health outcomes, and making predictions at population level to guide treatment choices and recommendations, d) finding the optimal dose of pharmacological interventions, and e) evaluating the credibility of results of network meta-analyses. Finally, I will discuss the potential of evidence synthesis in planning future clinical trials and the role of prospective network meta-analysis in regulatory setting.

(Before covering these cutting-edge topics in evidence synthesis, she will give us an introductory lecture on network meta-analysis as well.)

Lecturer

Professor Georgia Salanti, PhD
University of Bern, Institute of Social and Preventive Medicine

Georgia Salanti studied Mathematics in Greece, Epidemiology in Belgium and Sociology in the UK. She has a PhD in Statistics from the Ludwig-Maximillians University of Munich in Germany. She is now associate professor in Biostatistics and Epidemiology at the University of Bern in Switzerland.
She has been working in the field of evidence synthesis since 2003 and have contributed to the methodology of meta-analysis and systematic reviews. She has special interest in statistical methods for multi-parameter evidence synthesis. She has been working with the Cochrane Collaboration since 2004 and she currently co-directs the Cochrane Comparing Multiple Interventions Methods Group that shapes the Cochrane Collaboration’s policy for network meta-analysis. In 2013 she was one of the initiators of the PRISMA Extension Statement for Reporting of Network Meta-Analyses.
Since 2008 she has given more than 60 workshops, invited lectures and contributing talks on evidence synthesis and related methods and co-authored four book chapters on the topic. She has published in total more than 160 peer-reviewed scientific articles that have attracted over 10 000 citations. In 2010 she received the Award L’Oréal-UNESCO “Women in Science” for her research achievements.

古川からひと言

Georgia Salanti准教授は、メタアナリシスに関する統計学のリーダーの一人で、世界のガイドラインを変えるような系統的レビューを数多く担当してこられました。幸いに、私も最近でも、

• Cipriani A, Furukawa TA, Salanti G, Chaimani A, Atkinson LZ, Ogawa Y, Leucht S, Ruhe HG, Turner EH, Higgins JPT, Egger M, Takeshima N, Hayasaka Y, Imai H, Shinohara K, Tajika A, Ioannidis JPA & Geddes JR (2018) Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis. Lancet, 391, 1357-1366.
• Furukawa TA, Cipriani A, Cowen PJ, Leucht S, Egger M & Salanti G (in press) Optimal dose of selective serotonin reuptake inhibitors, venlafaxine and mirtazapine in major depression: Systematic review and dose-response meta-analysis. Lancet Psychiatry.

という、重要なメタアナリシスでご指導をいただきました。

Salanti准教授は h-indexがこの若さで47もあり、さらに素晴らしいことに、hot paper（過去2年間の引用がトップ0.1％）が2本、highly cited paper（引用が分野でトップ1％）が25本という、驚異的な影響力を持った研究者でいらっしゃいます。その一方で、説明が丁寧で分かりやすい！

Salanti准教授がこの度JSPSの外国人招へい研究者として、健康増進･行動学分野に2ヶ月間滞在されることになりましたので、これを機会に、ぜひKUSPHで統計学や疫学にご興味のある研究者と交流を深めていただく機会となりましたら、幸いです。